ABSTRACT
Objetivo: Comprender las experiencias de personas con gota sobre sus causas y desencadenantes, tratamientos y medidas terapéuticas recomendadas e impacto de vivir con este problema. Sujetos y métodos: Estudio cualitativo descriptivo. Muestreo opinático, buscando variabilidad discursiva según género, edad, posición socioeconómica y tratamientos. Se hicieron 3 grupos focales con 11, 6 y 7 personas, siguiendo un guion de temas preestablecido. Análisis siguiendo procedimientos del análisis de contenido temático. Resultados: Participaron 19 varones y 5 mujeres de diferentes edades, posición socioeconómica y tratamientos. Comorbilidades frecuentes: hipertensión e hipercolesterolemia. Como causas de gota mencionaron la genética y la falta de eliminación renal del urato. Refirieron escaso conocimiento de las causas, y necesitar más explicaciones sobre las mismas. Como desencadenantes del ataque identificaron: excesos alimentarios y/o enólicos, traumatismos, estrés o no seguir el tratamiento. Enumeraron diversos tratamientos farmacológicos y expresaron preocupación por sus posibles efectos adversos. Destacaron dificultades de adherencia a las recomendaciones. También describieron medidas no farmacológicas: descanso, frío, calzado adecuado, andar, beber agua y dieta. La gota crónica tiene un impacto importante en la vida diaria de pacientes y familiares. El dolor invalida y comporta dificultades para realizar actividades cotidianas. Refirieron sentirse irritables y con cambios de humor, que repercuten en sus relaciones familiares. Conclusiones: Estos hallazgos aportan propuestas para mejorar la atención de las personas con gota. Se recomienda mejorar la información sobre sus causas, los desencadenantes de la crisis, las recomendaciones alimentarias y el ejercicio. Las causas tras la variabilidad de recomendaciones sobre tratamientos y hábitos de vida deberían analizarse en profundidad.(AU)
Objective: To delve into the experiences of people living with gout regarding its causes and triggers, recommended treatments and therapeutic measures, and the impact of living with this problem. Subjects and methods: Descriptive qualitative study. Opinion sampling, looking for discursive variability according to sex, age, socioeconomic position and treatments. Three focus groups were made with 11, 6 and 7 people, following a pre-established script of topics. Analysis following thematic content analysis procedures. Results: Participants were 19 men and 5 women, of different ages, socioeconomic status and treatments. Frequent comorbidities: hypertension and hypercholesterolemia. Genetics and the lack of renal elimination of urate were mentioned as causes of gout. They reported little knowledge of the causes and need more explanations about them. As triggers of the attack they identified: excess food and / or alcohol, trauma, stress or not following the treatment. Various drug treatment and expressed concern about their possible adverse effects were listed. Difficulties in adherence to the recommendations were also described. Non-pharmacological measures: rest, cold, proper footwear, walking, drinking water, and diet were also described. Chronic gout has an important impact on the daily life of patients and their families. Pain invalidates and leads to difficulties in performing daily activities. Irritations and mood swings were reported, which affect their family relationships. Conclusions: These findings provide proposals to improve the care of people with gout. Information on its causes, the triggers of the crisis, dietary recommendations and exercise should be improved. The variability of treatments and recommendations on lifestyle should be analysed in depth.(AU)
Subject(s)
Humans , Male , Female , Focus Groups , Gout , Comorbidity , Clinical Evolution , Epidemiology, Descriptive , Qualitative ResearchABSTRACT
OBJECTIVE: To delve into the experiences of people living with gout regarding its causes and triggers, recommended treatments and therapeutic measures, and the impact of living with this problem. SUBJECTS AND METHODS: Descriptive qualitative study. Opinion sampling, looking for discursive variability according to sex, age, socioeconomic position and treatments. Three focus groups were made with 11, 6 and 7 people, following a pre-established script of topics. Analysis following thematic content analysis procedures. RESULTS: Participants were 19 men and 5 women, of different ages, socioeconomic status and treatments. Frequent comorbidities: hypertension and hypercholesterolemia. Genetics and the lack of renal elimination of urate were mentioned as causes of gout. They reported little knowledge of the causes and need more explanations about them. As triggers of the attack they identified: excess food and/or alcohol, trauma, stress or not following the treatment. Various drug treatment and expressed concern about their possible adverse effects were listed. Difficulties in adherence to the recommendations were also described. Non-pharmacological measures: rest, cold, proper footwear, walking, drinking water, and diet were also described. Chronic gout has an important impact on the daily life of patients and their families. Pain invalidates and leads to difficulties in performing daily activities. Irritations and mood swings were reported, which affect their family relationships. CONCLUSIONS: These findings provide proposals to improve the care of people with gout. Information on its causes, the triggers of the crisis, dietary recommendations and exercise should be improved. The variability of treatments and recommendations on lifestyle should be analysed in depth.
Subject(s)
Gout , Male , Humans , Female , Focus Groups , Gout/drug therapy , Qualitative Research , Uric Acid , ExerciseABSTRACT
Background: Gout is the most common type of inflammatory arthritis. Nonsteroidal anti-inflammatory drugs, corticosteroids, and colchicine are the first-line agents, although they are contraindicated in many patients. Blockade of IL-1 with anakinra can be an alternative. Objective: To present a case series of 10 difficult-to-treat gout patients treated with anakinra and perform a scoping review of the effectiveness and safety of anakinra in gout patients. Methods: A total of 1,519 citations were screened. The reviewers ran a two-stage screening process by title/abstract and full-text reading. Thirty-eight articles finally met the selection criteria and were included for data extraction and synthesis. Experience in difficult-to treat and complex clinical scenarios, such as active infection, hemodialysis, and transplantation, were specifically described. Results: The study sample comprised 551 patients, from whom 648 flares were finally analyzed. The mean age was 57.9 years, and 82.9% were men. The clinical presentation was polyarticular in 47.5% and tophaceous in 66.9%. Sixty-five patients with an active infection, 41 transplanted patients and 14 in haemodyalisis treated with anakinra are described. More than half of the patients had >1 associated comorbidity. Anakinra was effective both for flares (94%) and for long-term treatment (91%) and well tolerated. In the case of flares, 34 (6.7%) adverse effects were registered. Adverse events were more prevalent in long-term treatment. Conclusion: Anakinra was effective and safe for management of gout flares in difficult-to-treat patients. It has been used in multiple complex scenarios, such as active infections, dialysis, transplantation, chronic kidney disease, and polyarticular gout. Anakinra has also proven effective as long-term treatment, although there are more concerns about its safety.
Subject(s)
Humans , Male , Female , Severe acute respiratory syndrome-related coronavirus , Pandemics , Coronavirus Infections/diagnosis , Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Hospitalization , Patient Care Team/organization & administration , Indicators of Morbidity and Mortality , Hospitals, Urban , Remote Consultation , Primary Health Care/organization & administration , Primary Health Care/statistics & numerical data , Epidemiology, DescriptiveSubject(s)
COVID-19/therapy , Hospitalization/statistics & numerical data , Patient Care Team/organization & administration , Primary Health Care/organization & administration , Referral and Consultation/organization & administration , Urban Health Services/organization & administration , Adolescent , Adult , Aged , Aged, 80 and over , COVID-19/diagnosis , COVID-19/epidemiology , Comorbidity , Female , Humans , Male , Middle Aged , Outcome and Process Assessment, Health Care , Pandemics , Primary Health Care/methods , Primary Health Care/statistics & numerical data , Referral and Consultation/statistics & numerical data , Severity of Illness Index , Spain/epidemiology , Urban Health Services/statistics & numerical data , Young AdultABSTRACT
OBJECTIVE: To evaluate the effectiveness of two management programs on patients with chronic obstructive pulmonary disease (COPD). DESIGN: A study with a quasi-experimental design was used to evaluate the effectiveness of two interventions (I1, I2) for the care of patients with COPD after a mean follow-up of 31.2months. SETTING: Primary Care Centres in two Barcelona Health Areas and their referral hospitals. PARTICIPANTS: Patients with COPD selected by simple random sampling using any disease code corresponding to COPD. INTERVENTIONS: I1: Integrated management program that was optimised and coordinated the resources. Training was given, as well as quality control of spirometry. I2: Isolated interventions like a call-centre. Care circuits and computerised clinical notes were shared. MAIN MEASUREMENTS: Variables were recorded as regards lung function, severity, use of inhalers, lifestyles, quality of life, and exacerbations. RESULTS: Of the 393 patients evaluated at the beginning, 120 and 104 (I1 and I2, respectively) received the final evaluation. With I1, there was a reduction in patients who smoked (P=.034). Lung function and quality of life did not change significantly in either group, but shortness of breath was slightly worse. There was an increase in the correct use of inhalers, although it only reached 48% and 61% with interventions I1 and I2, respectively. The percentage of patients with exacerbations decreased with I1 compared to that of I2 (P<.001), and there were less hospital admissions due to exacerbations with I2 compared to I1 (P<.003]). CONCLUSIONS: Both interventions achieved significant improvements, and no overall worsening of a chronic and progressive disease as is COPD.
Subject(s)
Pulmonary Disease, Chronic Obstructive/therapy , Aged , Female , Humans , Male , Treatment OutcomeABSTRACT
Fundamento y objetivo: La enfermedad pulmonar obstructiva crónica (EPOC) es un proceso que cursa con inflamación sistémica. El objetivo del estudio fue evaluar la asociación entre la inflamación sistémica, medida con la concentración de proteína C reactiva (PCR) en sangre capilar, y distintos parámetros clínico-funcionales de la enfermedad. Pacientes y método: Se evaluó una muestra aleatoria de 413 pacientes con EPOC atendidos en 31 centros de salud de Barcelona. Se registraron antecedentes, variables antropométricas, hábitos tóxicos, tratamientos, Chronic Respiratory Questionnaire (CRQ, «Cuestionario de Enfermedades Respiratorias Crónicas») y escala de disnea. Se realizó una espirometría y se determinó la concentración de CO en aire espirado y de la PCR en sangre capilar. Resultados: La media (desviación estándar) de edad fue 72 (8,4) años y la del volumen espirado en el primer segundo (FEV1) posbroncodilatador de 1,65 (0,65) l. La correlación fue negativa entre PCR y FEV1 posbroncodilatador (r=-0,25, p<0,001), así como entre PCR y puntuación en el CRQ (r=-0,098, p=0,048), y fue positiva entre PCR y CO en aire espirado (r=0,1, p=0,039). La proporción de pacientes con PCR elevada fue superior en los estadios GOLD más avanzados (p<0,001), en aquellos con más disnea (p=0,042), en los tratados con glucocorticoides inhalados (p=0,018) y en aquellos que habían ingresado por agudización en el último año (p=0,026). El análisis multivariante indicó como determinantes independientes de la PCR el FEV1 posbroncodilatador y la concentración de CO en aire espirado. Conclusión: En los pacientes con EPOC, el tabaquismo activo y el grado de la obstrucción al flujo aéreo se asocian a una mayor intensidad de la respuesta inflamatoria sistémica medida por la PCR (AU)
Background and objetive: Chronic obstructive pulmonary disease (COPD) is characterized by a systemic inflammation. The aim of this study was to evaluate the association between systemic inflammation, measured with C reactive protein (CRP), and clinical and functional outcomes of the disease. Patients and methods: A randomized sample of 413 COPD patients from 31 primary health care centers of Barcelona was evaluated. Medical history, anthropometric measurements, toxic habits, treatments, Chronic Respiratory Questionnaire (CRQ) and dyspnea were registered. Spirometry, exhaled CO concentration and CRP in capillary blood were performed. Results: Median (standard deviation) of the age was 72 (8.4) years and forced expiratory volume in one second (FEV1) postbronchodilatador 1.65 (0.65) l. The correlation was negative between CRP and FEV1 postbronchodilatador(r=-0.25, P<0.001) and between CRP and CRQ scores (r=-0.098, P=0.048) and positive between CRP and CO (r=0.1, P=0.039). The ratio of patients with elevated CRP was higher in advanced GOLD stage (P<0.001), worst dyspnea (P=0.042), patients treated with inhaled corticosteroids (P=0.018) and if they had been hospitalized during the last year (P=0.026). The multivariant analysis showed, as independent factors of elevated CRP, FEV1 postbronchodilator and CO concentration. Conclusion: In COPD patients, active smoking habit and the airway's obstruction degree are associated with a greater intensity of the inflammatory systemic response measured by the CRP (AU)
Subject(s)
Humans , Pulmonary Disease, Chronic Obstructive/physiopathology , Systemic Inflammatory Response Syndrome/physiopathology , Inflammation Mediators/analysis , Inflammation/physiopathology , C-Reactive Protein/analysis , Smoking/adverse effectsABSTRACT
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is characterized by a systemic inflammation. The aim of this study was to evaluate the association between systemic inflammation, measured with C reactive protein (CRP), and clinical and functional outcomes of the disease. PATIENTS AND METHODS: A randomized sample of 413 COPD patients from 31 primary health care centers of Barcelona was evaluated. Medical history, anthropometric measurements, toxic habits, treatments, Chronic Respiratory Questionnaire (CRQ) and dyspnea were registered. Spirometry, exhaled CO concentration and CRP in capillary blood were performed. RESULTS: Median (standard deviation) of the age was 72 (8.4) years and forced expiratory volume in one second (FEV(1)) postbronchodilatador 1.65 (0.65) l. The correlation was negative between CRP and FEV(1) postbronchodilatador(r=-0.25, P<0.001) and between CRP and CRQ scores (r=-0.098, P=0.048) and positive between CRP and CO (r=0.1, P=0.039). The ratio of patients with elevated CRP was higher in advanced GOLD stage (P<0.001), worst dyspnea (P=0.042), patients treated with inhaled corticosteroids (P=0.018) and if they had been hospitalized during the last year (P=0.026). The multivariant analysis showed, as independent factors of elevated CRP, FEV(1) postbronchodilator and CO concentration. CONCLUSION: In COPD patients, active smoking habit and the airway's obstruction degree are associated with a greater intensity of the inflammatory systemic response measured by the CRP.
Subject(s)
C-Reactive Protein/metabolism , Inflammation/etiology , Pulmonary Disease, Chronic Obstructive/physiopathology , Adult , Aged , Aged, 80 and over , Biomarkers/blood , Female , Forced Expiratory Volume , Humans , Inflammation/blood , Logistic Models , Male , Middle Aged , Multivariate Analysis , Prognosis , Pulmonary Disease, Chronic Obstructive/blood , Pulmonary Disease, Chronic Obstructive/diagnosis , Pulmonary Disease, Chronic Obstructive/etiology , Severity of Illness Index , Smoking/adverse effects , SpirometryABSTRACT
The aging of the populations in Western countries entails an increase in chronic diseases, which becomes evident with the triad of age, comorbidities and polymedication. chronic obstructive pulmonary disease represents one of the most important causes of morbidity and mortality, with a prevalence in Spain of 10.2% in the population aged 40 to 80. In recent years, it has come to be defined not only as an obstructive pulmonary disease, but also as a systemic disease. Some aspects stand out in its management: smoking, the main risk factor, even though avoidable, is an important health problem; very important levels of underdiagnosis and little diagnostic accuracy, with inadequate use of spirometry; chronic patient profile; exacerbations that affect survival and cause repeated hospitalizations; mobilization of numerous health-care resources; need to propose integral care (health-care education, rehabilitation, promotion of self-care and patient involvement in decision-making).
Subject(s)
Primary Health Care , Pulmonary Disease, Chronic Obstructive/therapy , Age Distribution , Chronic Disease/epidemiology , Comorbidity , Consensus Development Conferences as Topic , Hospitalization/statistics & numerical data , Humans , National Health Programs , Patient Education as Topic , Practice Guidelines as Topic , Pulmonary Disease, Chronic Obstructive/diagnosis , Pulmonary Disease, Chronic Obstructive/epidemiology , Pulmonary Disease, Chronic Obstructive/prevention & control , Quality of Life , Spain/epidemiology , SpirometryABSTRACT
El envejecimiento de la población en los países occidentales conlleva un incremento de las enfermedades crónicas. Estas se manifiestan mediante la tríada edad, comorbilidad y polimedicación. La enfermedad pulmonar obstructiva crónica representa una de las causas más importantes de morbimortalidad, con una prevalencia en España del 10,2% en población de 40 a 80 años. En los últimos años ha pasado a definirse no solo como una enfermedad obstructiva pulmonar sino también como una enfermedad sistémica. Algunos aspectos destacan en su manejo: el tabaquismo, principal factor de riesgo, aun siendo evitable, es un problema de salud importante; cifras de infradiagnóstico muy importantes y escasa precisión diagnóstica, con inadecuado uso de la espirometría forzada; perfil de paciente crónico; agudizaciones que afectan a la supervivencia y provocan ingresos repetidos; movilización de numerosos recursos en salud; necesidad de plantear una atención integrada (educación sanitaria, rehabilitación, promoción del autocuidado e implicación del paciente en la toma de decisiones)(AU)
The aging of the populations in Western countries entails an increase in chronic diseases, which becomes evident with the triad of age, comorbidities and polymedication. chronic obstructive pulmonary disease represents one of the most important causes of morbidity and mortality, with a prevalence in Spain of 10.2% in the population aged 40 to 80. In recent years, it has come to be defined not only as an obstructive pulmonary disease, but also as a systemic disease. Some aspects stand out in its management: smoking, the main risk factor, even though avoidable, is an important health problem; very important levels of underdiagnosis and little diagnostic accuracy, with inadequate use of spirometry; chronic patient profile; exacerbations that affect survival and cause repeated hospitalizations; mobilization of numerous health-care resources; need to propose integral care (health-care education, rehabilitation, promotion of self-care and patient involvement in decision-making)(AU)
Subject(s)
Humans , Pulmonary Disease, Chronic Obstructive/epidemiology , Wasting Disease, Chronic/epidemiology , Primary Health Care/methods , ComorbidityABSTRACT
There are several artists that have suffered rheumatic diseases. Even then, they continued their creative activity. Paul Klee suffered from systemic sclerosis, Dufy and Renoir suffered from rheumatoid arthritis and Gaudí and Boticelli had systemic-onset juvenile idiopathic arthritis. The famous noucentism sculptor, Manolo Hugué, presented chronic polyarthritis that suggested rheumatoid arthritis. Although he underwent several treatments, such as hydrotherapy or diathermic therapy, he had to stop sculpting. Using the chisel was too painful for his hands. He began, then, painting and composing poetry.
Subject(s)
Arthritis, Rheumatoid/history , Paintings/history , Sculpture/history , History, 19th Century , History, 20th Century , Humans , Male , SpainABSTRACT
Son varios los artistas que a pesar de haber sufrido enfermedades reumáticas, han proseguido de una manera u otra su actividad creadora. Paul Klee padeció una esclerosis sistémica, Raoul Dufy y Renoir padecieron artritis reumatoide y Gaudí y Boticelli sufrieron una artritis crónica juvenil. El destacado escultor noucentista Manolo Hugué presentó a los 55 años una poliartritis crónica compatible con una artritis reumatoide. A pesar de realizar diversos tratamientos, como la hidroterapia o la diatermia, debió abandonar parcialmente la escultura para dedicarse a la pintura y la poesía. El uso del cincel le hacía mucho daño en las manos(AU)
There are several artists that have suffered rheumatic diseases. Even then, they continued their creative activity. Paul Klee suffered from systemic sclerosis, Dufy and Renoir suffered from rheumatoid arthritis and Gaudí and Boticelli had systemic-onset juvenile idiopathic arthritis. The famous noucentism sculptor, Manolo Hugué, presented chronic polyarthritis that suggested rheumatoid arthritis. Although he underwent several treatments, such as hydrotherapy or diathermic therapy, he had to stop sculpting. Using the chisel was too painful for his hands. He began, then, painting and composing poetry(AU)
